PENTAGASTRIN

PENTAGASTRIN

Drug Category :
• Diagnostic aid
• gastric function

Indication: Used as a diagnostic aid for evaluation of gastric acid secretory function

Pharmacology: Pentagastrin is indicated as a diagnostic aid for evaluation of gastric acid secretory function. It is effective in testing for anacidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It is also effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection.

Mechanism of Action: The exact mechanism by which pentagastrin stimulates gastric acid, pepsin, and intrinsic factor secretion is unknown; however, since pentagastrin is an analogue of natural gastrin, it is believed that it excites the oxyntic cells of the stomach to secrete to their maximum capacity. Pentagastrin stimulates pancreatic secretion, especially when administered in large intramuscular doses. Pentagastrin also increases gastrointestinal motility by a direct effect on the intestinal smooth muscle. However, it delays gastric emptying time probably by stimulation of terminal antral contractions, which enhance retropulsion.

Precautions-

It should be given with care to patients with
Acute peptic ulceration
Hepatic or biliary tract disease.

Adverse effects-

Pentgastrin may cause a no GIT effects. It causes Nausea and abdominal cramps.
Tachycardia
Arrhythmia
Dizziness, allergic reactions
Incidence less frequent or rare:- fast heartbeat ,usually transient chills, dizziness, faintness, or lightheadedness, drowsiness, feeling of heaviness of arms and legs, headache, increased sweating, numbness, tingling, pain, or weakness in hands or feet, shortness of breath, unusual tiredness
DOSAGE-
6 micrograms/kg by SC injection, IM or Nasal Inhalation.